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首页> 外文期刊>Bulletin of the National Research Centre >Toxicological Potential to Mice of ~(14)C-arbaryl Bound Residues in Faba and Soybeans
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Toxicological Potential to Mice of ~(14)C-arbaryl Bound Residues in Faba and Soybeans

机译:蚕豆和大豆中〜(14)C-芳基结合残基对小鼠的毒理学潜力

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摘要

Sound faba and soybeans were treated with ~(14)C-carbaryl at a dose of 16 mg insecticide/kg grains and stored under local conditions. After 30 weeks of storage the amount of surface residues was 29%, 27% and the internal residues amounted to 56%, 60% in faba and soybeans, respectively. ~(14)C-Bound residues (non-extractable) after 30 weeks of storage was 5% and 6% in faba and soybeans, respectively. Feeding mice for 3 months with a diet containing ~(14)C-carbaryl bound residues in faba and soybeans revealed that these residues have a slight effect and no significant symptoms of toxicity towards mice were observed. A slight inhibition in both plasma and erythrocyte-cholinesterase activity was clear during the first 2 weeks of the experiment with both seeds. Haematological studies showed only a significant decrease in the white blood cell counts as compared with the control mice. The level of blood serum esterases showed a slight increase in liver and kidney functions as compared with controls. Significant differences were clear in kidney function where blood urea nitrogen was increased by (45%, 58%), and creatinine level was elevated by (20%, 28%) after 3 months of feeding with faba and soybeans, respectively.
机译:用〜(14)C-碳芳基以16 mg杀虫剂/ kg谷物的剂量处理健全的蚕豆和大豆,并在当地条件下储存。储存30周后,蚕豆和大豆的表面残留量分别为29%,27%和内部残留量分别为56%,60%。蚕豆和大豆中储存30周后〜(14)-C-残留(不可提取)分别为5%和6%。用在蚕豆和大豆中含有〜(14)C-碳芳基结合的残基的饮食喂养小鼠三个月后发现,这些残基具有轻微作用,并且未观察到对小鼠的明显毒性症状。在使用两种种子的实验的前两周内,血浆和红细胞胆碱酯酶活性均受到轻微抑制。血液学研究显示,与对照小鼠相比,白细胞计数仅显着减少。与对照组相比,血清酯酶水平显示肝和肾功能略有增加。分别喂食蚕豆和大豆三个月后,肾功能有明显差异,其中血液尿素氮增加了(45%,58%),肌酐水平增加了(20%,28%)。

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