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Efficacy and Cytotoxicity of Binary Mixtures as Root Canal Filling Solvents

机译：二元混合物的疗效和细胞毒性作为根管填充溶剂

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Objectives: This study reports the efficacy of two solvent mixtures on the dissolution of gutta-percha and AH Plus sealer, together with the cytotoxicity. Methods: Methyl ethyl ketone (MEK), orange oil, tetrachloroethylene, MEK/tetrachloroethylene (1:1), MEK/orange oil (1:1), and chloroform (control) were tested. Twelve groups ( = 15) of standardized stainless-steel molds filled with softened gutta-percha cones and twelve ( = 15) filled with AH Plus were immersed in the corresponding mixture or individual solvent, in an ultrasonic bath, for either 2 or 5 min. The effect of the solvents was assessed qualitatively by a topographical analysis (scanning electron microscopy) and chemical analysis (Fourier transform infrared spectroscopy), and quantitatively by a weight loss and viscoelastic property (dynamic mechanical analysis) evaluation. The cytotoxicity was assessed on MG63 human osteoblastic cells. Results: The mixtures did not show the formation of new compounds. Both presented significantly higher efficacies compared to their individual solvents, suggesting a synergistic effect. Their dissolution efficacy was similar to that of chloroform, showing high cytocompatibility. Conclusions: The proposed strategy, incorporating ultrasound agitation and profiting from the synergy of adequate solvents, might enhance root canal cleanliness allowing a single-step procedure to dissolve gutta-percha and the sealer remnants, while assuring cytocompatibility with the periapical tissues.
机译：目的：本研究报告了两种溶剂混合物对葛兰芹和αH加上封口溶解的疗效以及细胞毒性的疗效。方法：对甲基乙基酮（MEK），橙油，四氯乙烯，MEK /四氯乙烯（1：1），MEK /橙油（1：1）和氯仿（对照）进行了测试。填充有软化的Gutta-percha锥体的标准化不锈钢模具的12个（= 15）浸入相应的混合物或单独溶剂中，在超声浴中浸入2或5分钟。通过地形分析（扫描电子显微镜）和化学分析（傅里叶变换红外光谱）和化学分析（傅里叶变换红外光谱）和粘弹性（动态机械分析）评估定量评估溶剂的效果。在Mg63人骨细胞细胞上评估细胞毒性。结果：混合物未显示新化合物的形成。与各自的溶剂相比，两者都呈现出显着更高的疗效，表明协同效应。它们的溶出功效与氯仿类似的疗效相似，显示出高细胞组成性。结论：拟议的策略，纳入超声搅拌和从足够溶剂的协同作用的利用，可以增强根管清洁度，从而允许单步过程溶解Gutta-percha和封口残余物，同时确保与恐慌组织的细胞偶联性。

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