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首页> 美国卫生研究院文献>Clinical and Molecular Allergy : CMA >Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly
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Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly

机译：明智的选择：老年人哮喘的疗效和安全性的实际考虑

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The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a common belief attributes to asthma the definition of “rare” disease. Indeed, asthma in the elderly is often underdiagnosed or diagnosed as COPD, thus leading to undertreatment of improper treatment. This is also due to the heterogeneity of clinical and functional presentations of geriatric asthma, including the partial loss of reversibility and the lower occurrence of the allergic component in this age range. The older asthmatic patients are also characterized the coexistence of comorbid conditions that, in conjunction with age-associated structural and functional changes of the lung, may contribute to complicate the management of asthma. The current review addresses the main issues related to the management of allergic asthma in the geriatric age. In particular, the paper aims at revising current pharmacological and non pharmacological treatments for allergic asthmatics of advanced ages, primarily focusing on their safety and efficacy, although most behaviors are an arbitrary extrapolation of what has been tested in young ages. In fact, age has always represented an exclusion criterion for eligibility to clinical trials. Experimental studies and real life observations specifically testing the efficacy and safety of therapeutic approaches in allergic asthma in the elderly are urgently needed.
机译：在大多数年龄段的哮喘患病率与年龄较小的人群相似。然而，过去人们大体上否认了老年人可能患有过敏性哮喘的概念，并且普遍认为哮喘是“罕见”疾病的定义。确实，老年人的哮喘常常被误诊或诊断为COPD，因此导致治疗不当的治疗不足。这也是由于老年性哮喘临床和功能表现的异质性，包括该年龄范围内可逆性的部分丧失和变应性成分的发生率较低。老年哮喘患者的特征还在于合并症共存，与年龄相关的肺部结构和功能改变相结合，可能会使哮喘的治疗复杂化。当前的审查解决了与老年人年龄过敏性哮喘管理有关的主要问题。特别是，本文旨在修订当前针对高龄过敏性哮喘患者的药物和非药物治疗方法，主要侧重于其安全性和有效性，尽管大多数行为是对年轻人试验的任意推断。实际上，年龄始终代表有资格参加临床试验的排除标准。迫切需要进行实验研究和现实生活中的观察结果，具体测试老年人过敏性哮喘中治疗方法的有效性和安全性。

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