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The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression

机译：视黄酸受体-α调节剂ATRA和Ro415253相互调节人IL-5 + Th2细胞的增殖和细胞因子的表达

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BackgroundTh2 cytokine responses are enhanced by all trans retinoic acid (ATRA), the bioavailable form of vitamin A. Retinoic acid receptor alpha (RARα) is the high affinity receptor for ATRA that mediates these pro-Th2 effects. We have previously characterized two major human Th2 subpopulations: IL-5- Th2 (IL-5-, IL-4+, IL-13+) and IL-5+ Th2 cells (IL-5+, IL-4+, IL-13+), which represent less and more highly differentiated Th2 cells, respectively. We hypothesized that the pro-Th2 effects of ATRA may differentially affect these Th2 subpopulations.

机译：背景Th2细胞因子的反应可通过维生素A的生物利用形式全反式维甲酸（ATRA）来增强。维甲酸受体α（RARα）是ATRA的高亲和力受体，介导这些促Th2效应。我们之前已经鉴定了两个主要的人类Th2亚群：IL-5- Th2（IL-5-，IL-4 +，IL-13 +）和IL-5 + Th2细胞（IL-5 +，IL-4 +，IL） -13+），分别代表了分化程度越来越低的Th2细胞。我们假设ATRA的促Th2效应可能会差异地影响这些Th2亚群。

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期刊名称 Clinical and Molecular Allergy : CMA
作者
Daniel L Wansley; Yuzhi Yin; Calman Prussin;
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作者单位

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年(卷),期 2013(11),-1
年度 2013
页码 4
总页数 12
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Interleukin 5 All-trans retinoic acid T helper 2 Retinoic acid receptor alpha House dust mite antigen Retinoic acid response element;

机译：白介素5;全反式维甲酸;T辅助剂2;维甲酸受体α;屋尘螨抗原;维甲酸反应元件;

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1. The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression [J] . Daniel L Wansley, Yuzhi Yin, Calman Prussin Clinical and Molecular Allergy . 2013,第1期

机译：视黄酸受体-α调节剂ATRA和Ro415253相互调节人IL-5 + Th2细胞的增殖和细胞因子的表达
2. The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression [J] . Daniel L Wansley, Yuzhi Yin, Calman Prussin Clinical and Molecular Allergy . 2013,第1期

机译：视黄酸受体-α调节剂ATRA和Ro415253相互调节人类IL-5 + Th2细胞增殖和细胞因子表达
3. The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production [J] . Harry D Dawson, Gary Collins, Robert Pyle, BMC Immunology . 2008,第1期

机译：维甲酸受体-α介导人类T细胞活化以及Th2细胞因子和趋化因子的产生
4. RETINOIC ACID IMPROVES CELL PROLIFERATION AND ANTIBODY PRODUCTION OF HUMAN HYBRIDOMAS NONPROLIFERATIVE IN A FRUCTOSE-BASED MEDIUM [C] . Yuichi Inoue, Sanetaka Shirahata, Yasushi Sugimoto Annual Meeting of the Japanese Association for Animal Cell Technology . 2006

机译：维甲酸在果糖的培养基中改善了人杂交瘤的细胞增殖和抗体产生了人杂交瘤的抗体产生
5. Diversity of Cytokine Expression Patterns in the Th1-Dominated Human Anti-Influenza CD4 T Cell Response Is Due To Both Variable Expression of Cytokines by Committed Th1 Cells, and a Minor Population of Uncommitted IL-2+IFNγ- Thpp Cells [D] . Deng, Nan 2014

机译：Th1为主的人类抗流感CD4 T细胞反应中细胞因子表达模式的多样性是由于既定的Th1细胞可变表达细胞因子，以及少数未定型的IL-2 +IFNγ-Thpp细胞引起的。
6. The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production [O] . Harry D Dawson, Gary Collins, Robert Pyle, 2008

机译：维甲酸受体-α介导人类T细胞活化以及Th2细胞因子和趋化因子的产生
7. The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression [O] . Daniel L Wansley, Yuzhi Yin, Calman Prussin 2013

机译：视黄酸受体-α调节剂ATRA和Ro415253相互调节人IL-5 + Th2细胞的增殖和细胞因子的表达

The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression

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