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Remission of severe aphthous stomatitis of celiac disease with etanercept

机译:依那西普缓解腹腔疾病的严重口疮性口炎

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摘要

Celiac disease is a common autoimmune disease triggered by gluten-containing foods (wheat, barley and rye) in genetically predisposed individuals. We present a patient with celiac disease complicated by severe aphthous stomatitis resulting in impairing swallowing, chewing and speaking. This led to weight loss, psychosocial problems as well as inability to perform her work. A variety of topical and systemic medications used resulted in either no improvement or only partial alleviation of the patient’s symptoms. After informed consent, etanercept was initiated and resulted in complete remission of aphthous stomatitis, decrease in arthralgia and fatigue and considerable improvement in her quality of life. The use of newer biological agents for selected and severe manifestations of celiac disease may lead to improved morbidity in these patients, but more studies are needed to determine long-term efficacy as well as safety of these drugs in the mucosal and/or systemic complications of this disease.
机译:乳糜泻是一种常见的自身免疫性疾病,由遗传易感人群中的含麸质食物(小麦,大麦和黑麦)引发。我们介绍了患有严重口疮性口炎并导致吞咽,咀嚼和说话障碍的并发乳糜泻的患者。这导致体重减轻,社会心理问题以及无法执行她的工作。所使用的各种局部和全身性药物均无法改善患者的症状,或者只能部分缓解患者的症状。知情同意后,开始使用依那西普,并导致口疮性口炎完全缓解,关节痛和疲劳减轻以及生活质量的显着改善。在某些特定的严重腹腔疾病表现中使用新的生物制剂可能会改善这些患者的发病率,但是还需要进行更多的研究来确定这些药物在粘膜和/或全身并发症中的长期疗效以及安全性。这种病。

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