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Different clinical allergological features of Taenia solium infestation

机译:猪带so虫感染的不同临床过敏特征

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摘要

The tapeworm Taenia (T.) solium can be responsible for two different conditions: taeniasis and cysticercosis. Helminth infections in human host cause an immune response associated with elevated levels of IgE, tissue eosinophilia and mastocytosis, and with the presence of CD4+ T cells that preferentially produce IL-4, IL-5, and IL-13. Individuals exposed to helminth infections may have allergic inflammatory responses to parasites and parasite antigens. PubMed search of human cases of allergic reactions occurring during T. solium infestation was performed combining the terms (allergy, urticaria, angioedema, asthma, anaphylaxis) with T. solium. A study was considered eligible for inclusion in the review if it reported data on patients with T. solium infestation who had signs or symptoms of allergy. In literature we found six articles reporting the association between an allergic reaction and T. solium infestation: two cases of urticaria, two cases of relapsing angioedema, one case of asthma and two cases of anaphylaxis. Despite the large diffusion of T. solium infestation, we found only a few cases of concomitant allergic reaction and the presence of Taenia in the host. The association between T. solium infestation and allergic manifestations has never been clearly demonstrated, and in absence of a well-documented causality the hypotheses are merely speculative. Therefore, the association between Taenia infection and allergy needs to be thoroughly studied to better clarify if this association may really exist and which is the pathogenetic mechanism supported.
机译:worm虫Ta虫(T.)可能是造成两种不同状况的原因:虫病和囊虫病。人宿主中的蠕虫感染会导致免疫应答,与IgE水平升高,组织嗜酸性粒细胞增多和肥大细胞增多以及CD4 + T细胞的存在有关,这些CD4 + T细胞优先产生IL-4,IL-5和IL-13。接触蠕虫感染的个体可能会对寄生虫和寄生虫抗原产生过敏性炎症反应。结合T. solium的术语(过敏,荨麻疹,血管性水肿,哮喘,过敏反应),对在T. solium侵染期间发生的过敏反应的人类病例进行PubMed搜索。如果一项研究报告了有过敏迹象或症状的T. solium侵染患者的数据,则认为该研究符合纳入条件。在文献中,我们发现有六篇文章报道了变态反应与T虫的侵染之间的关系:两例荨麻疹,两例复发性血管水肿,一例哮喘和两例过敏反应。尽管T. solium侵染扩散很大,但我们仅发现少数几例过敏反应和宿主中出现Ta虫病。从来没有清楚地证明过T. solium侵染和过敏表现之间的关联,并且在没有充分记录的因果关系的情况下,这些假设仅仅是推测性的。因此,需要全面研究Ta虫感染与过敏之间的关联,以更好地阐明这种关联是否确实存在,这是所支持的致病机制。

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