HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4

机译：HIV-1 Nef通过与CXCR4相互作用促进人类嗜碱性粒细胞和肥大细胞的迁移和趋化因子合成

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BackgroundThe Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal environment for viral replication, e.g. by reducing the ability of infected cells to induce an immune response.

机译：背景Nef蛋白可以在感染HIV-1的患者血浆中检测到，并在HIV-1的发病机理中起作用。感染初期产生的Nef是创造理想的病毒复制环境的基础，例如通过降低感染细胞诱导免疫反应的能力。

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期刊名称 Clinical and Molecular Allergy : CMA
作者
Francesca Wanda Rossi; Nella Prevete; Felice Rivellese; Antonio Lobasso; Filomena Napolitano; Francescopaolo Granata; Carmine Selleri; Amato de Paulis;
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作者单位

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年(卷),期 2016(14),-1
年度 2016
页码 15
总页数 9
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Mast Cells Basophils Nef CXCR4 CXCL12/SDF-1α;

机译：肥大细胞;嗜碱性粒细胞;Nef;CXCR4;CXCL12 /SDF-1α;

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专利

1. HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4 [J] . Francesca Wanda Rossi, Nella Prevete, Felice Rivellese, Clinical and Molecular Allergy . 2016,第1期

机译：HIV-1 Nef通过与CXCR4相互作用促进人类嗜碱性粒细胞和肥大细胞的迁移和趋化因子合成
2. HIV-1 Envelope gp41 Peptides Promote Migration of Human FcepsilonRI(+) Cells and Inhibit IL-13 Synthesis Through Interaction with Formyl Peptide Receptors. [J] . De Paulis A, Florio G, Prevete N, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2002,第8期

机译：HIV-1信封gp41肽促进人类FcepsilonRI（+）细胞迁移并通过与甲酰肽受体相互作用抑制IL-13合成。
3. HIV-1 Envelope gp41 Peptides Promote Migration of Human FcεRI+ Cells and Inhibit IL-13 Synthesis Through Interaction with Formyl Peptide Receptors [J] . Amato de Paulis, Giovanni Florio, Nella Prevete, The journal of immunology . 2002,第8期

机译：HIV-1信封gp41肽促进人类FcεRI+细胞的迁移并通过与甲酰肽受体的相互作用抑制IL-13合成
4. Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FcepsilonRI- and/or CCR1-engaged mast cells using protein chip technology [C] . Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Symposium on Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease . 2005

机译：CC趋化因子及其受体在肥大细胞生物学多个方面的作用：使用蛋白质芯片技术的Fcepsilonri-and-/或CCR1接合肥大细胞的比较蛋白质分析
5. Proinflammatory cytokine / chemokine expression in human astrocytes: Induction by HIV-1 Nef. [D] . Liu, Xun. 2014

机译：人星形胶质细胞中促炎细胞因子/趋化因子的表达：HIV-1 Nef的诱导。
6. Inhibition of Chemokine (CXC Motif) Ligand 12/Chemokine (CXC Motif) Receptor 4 Axis (CXCL12/CXCR4)-mediated Cell Migration by Targeting Mammalian Target of Rapamycin (mTOR) Pathway in Human Gastric Carcinoma Cells [O] . Guang Chen, Si-Meng Chen, Xiang Wang, 2012

机译：通过靶向人胃癌细胞中雷帕霉素（mTOR）途径的哺乳动物靶标抑制趋化因子（CXC母体）配体12 /趋化因子（CXC母体）受体4轴（CXCL12 / CXCR4）介导的细胞迁移。
7. HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4 [O] . 2016

机译：HIV-1 Nef通过与CXCR4相互作用促进人类嗜碱性粒细胞和肥大细胞的迁移和趋化因子合成
8. Human Basophils and Mast Cells [R] . MacGlashan, D. J. , Lavens-Phillips, S. , Miura, K. , 1999

机译：人类嗜碱性粒细胞和肥大细胞

HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4

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