Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4

机译：产生白介素17的蜕膜CD4 + T细胞也产生白细胞介素4时不会对人类怀孕有害。

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BackgroundTrophoblast expressing paternal HLA-C antigens resemble a semiallograft, and could be rejected by maternal CD4+ T lymphocytes. We examined the possible role in human pregnancy of Th17 cells, known to be involved in allograft rejection and reported for this reason to be responsible for miscarriages. We also studied Th17/Th1 and Th17/Th2 cells never investigated before. We defined for the first time the role of different Th17 subpopulations at the embryo implantation site and the role of HLA-G5, produced by the trophoblast/embryo, on Th17 cell differentiation.

机译：背景表达母细胞HLA-C抗原的滋养细胞类似于同种异体移植，并且可能被母体CD4 + T淋巴细胞排斥。我们研究了已知参与同种异体移植排斥反应的Th17细胞在人类妊娠中的可能作用，并据此报道了造成流产的原因。我们还研究了以前从未研究过的Th17 / Th1和Th17 / Th2细胞。我们首次定义了不同的Th17亚群在胚胎着床部位的作用，以及滋养细胞/胚胎产生的HLA-G5在Th17细胞分化中的作用。

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期刊名称 Clinical and Molecular Allergy : CMA
作者
Letizia Lombardelli; Federica Logiodice; Maryse Aguerre-Girr; Ornela Kullolli; Herman Haller; Ysabel Casart; Alain Berrebi; Fatima-Ezzahra L’Faqihi-Olive; Valérie Duplan; Sergio Romagnani; Enrico Maggi; Daniel Rukavina; Philippe Le Bouteiller; Marie-Pierre Piccinni;
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年(卷),期 2016(14),-1
年度 2016
页码 1
总页数 14
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
Th17 Pregnancy IL-17 IL-4 Spontaneous abortion Ectopic pregnancy;

机译：Th17;妊娠;IL-17;IL-4;自然流产;异位妊娠;

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专利

1. Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4 [J] . Letizia Lombardelli, Federica Logiodice, Maryse Aguerre-Girr, Clinical and Molecular Allergy . 2016,第1期

机译：产生白介素17的蜕膜CD4 + T细胞也产生白细胞介素4时不会对人类怀孕有害。
2. Interleukin-17-producing decidual CD4+T cells are not deleterious for human pregnancy when they also produce Interleukin-4 [J] . Lombardelli L., Logiodice F., Aguerre-Girr M., Journal of Reproductive Immunology . 2017,第期

机译：当它们也产生白细胞介素-4时，产生白细胞介素-17产生的蜕膜CD4 + T细胞对人体妊娠并不有害
3. Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy [J] . Federica Logiodice, Letizia Lombardelli, Ornela Kullolli, International Journal of Molecular Sciences . 2019,第2期

机译：产生蜕膜白介素22的CD4 + T细胞（Th17 / Th0 / IL-22 +和Th17 / Th2 / IL-22 +，Th2 / IL-22 +，Th0 / IL-22 +），也产生IL-4，参与怀孕的成功
4. DEVELOPMENT AND DIFFERENTIATION OF HUMAN DECIDUAL GRANULOCYTES DURING EARLY PREGNANCY [C] . R. Demir, U.A. Kayisli, E. T. Korgun, International congress on electron microscopy . 2002

机译：妊娠早期人蜕膜粒细胞的开发与分化
5. Decidual prolactin-related protein: Biochemical and biological characterization and patterns of gene expression during pregnancy. [D] . Rasmussen, Christine Ann. 1996

机译：蜕膜催乳素相关蛋白：怀孕期间的生化和生物学特性以及基因表达模式。
6. Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+ Th2/IL-22+ Th0/IL-22+) Which Also Produce IL-4 Are Involved in the Success of Pregnancy [O] . Federica Logiodice, Letizia Lombardelli, Ornela Kullolli, 2019

机译：产生蜕膜白介素22的CD4 + T细胞（Th17 / Th0 / IL-22 +和Th17 / Th2 / IL-22 +Th2 / IL-22 +Th0 / IL-22 +）也产生IL-4参与成功怀孕
7. Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce Interleukin-4 [O] . L. Lombardelli, F. Logiodice, M. Aguerre-Girr, 2017

机译：当它们也产生白细胞介素-4时，产生白细胞介素-17产生的蜕膜CD4 + T细胞对人体妊娠并不有害

Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4

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