首页> 美国卫生研究院文献>Frontiers in Endocrinology >A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese
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A Study on the Association Between Polymorphisms in the Cytochrome P450 Family 17 Subfamily A Member 1 Gene Region and Type 2 Diabetes Mellitus in Han Chinese

机译:中国汉族人细胞色素P450家族17亚家族成员1基因区多态性与2型糖尿病的相关性研究

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摘要

BackgroundCytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene encodes a key enzyme in the synthesis and metabolism of steroid hormones and has been associated with various factors, such as hypertension, insulin resistance, and polycystic ovary syndrome. However, whether the gene was associated with type 2 diabetes mellitus (T2DM) has not been reported yet. Therefore, we sought to investigate whether CYP17A1 was associated with T2DM and related traits among Han Chinese.
机译:背景细胞色素P450家族17亚家族A成员1(CYP17A1)基因编码类固醇激素合成和代谢中的关键酶,并与多种因素相关,例如高血压,胰岛素抵抗和多囊卵巢综合征。但是,该基因是否与2型糖尿病(T2DM)相关尚无报道。因此,我们试图调查CYP17A1是否与汉族人群的T2DM及其相关性状有关。

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