目的 观察唑来膦酸联合放疗治疗肺癌骨转移患者的疗效.方法 对81例肺癌骨转移患者进行随机临床研究,试验组41例应用注射用唑来膦酸4mg+局部放疗;对照组40例采用单纯放疗.结果 试验组和对照组治疗结束时疼痛缓解率分别为87.8% 和77.5%,治疗结束3个月时疼痛缓解率分别为82.9% 和62.5%,生存质量改善率分别为85.4%和67.5%,新发现骨转移时间试验组较对照组延长.结论 唑来膦酸联合放疗对骨转移止痛疗效优于单纯放疗,止痛维持时间较长,骨转移进展时间延长,生活质量提高明显.%Objective To evaluate the efficacy of zoledronic acid combined with radiotherapy for lung cancer patients with bone metastases. Methods Eighty one lung cancer patients with bone metastases were randomly assigned to receive zoledronic acid (4mg, iv) combined with radiotherapy (DT4000cGy/20f, combination group, n=41) and radiotherapy alone (control group, n=40). The efficacy of treatment was compared between two groups. Results The pain relief rates immediately after treatment and 3 months after treatment in combination and control groups were 87.8%, 82.9% and 77.5%, 62.5%, respectively. The life rates of life quality improvement in combination and control groups were 85.4% and 67.5%, respectively. The time of new bone metastases in combination group was longer than that in control group. Conclusion Zoledronic acid combined with radiotherapy for bone metastasis in lung cancer patients was more effective than radiotherapy alone.
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