目的探讨影响老年抑郁症患者预后的相关因素。方法收集住院或门诊就诊的87例老年抑郁症患者的一般资料，并进行生活事件量表（LES）、艾森克人格问卷（EPQ）、简易智力状态检查表（MMSE）和社会支持评定量表（SSRS）等因子评定，采用大体功能评定量表（GAS）评定老年抑郁症患者的预后疗效，并根据GAS分值分组，GAS≤60分视为预后差，作为研究组；GAS＞60分视为预后好，作为对照组。通过logistic回归分析，探讨影响老年抑郁症患者预后的相关因素。结果87例老年抑郁症患者中疗效差者占37.9%。两组患者在起病形式、治疗是否恰当、治疗依从性、合并慢性躯体疾病、负性生活事件值、对社会支持的利用度、EPQ的N维度分值及MMSE总分等因子方面的差异均有统计学意义（均P＜0.05），经多元logistic回归分析发现，影响老年抑郁症预后的主要因素为：治疗依从性、慢性躯体疾病、EPQ标准N维度分值、合并精神病症状及对支持的利用度。结论老年抑郁症患者的预后可能受精神病理学、神经心理学和家庭社会等多种因素的影响，应从多方位着手，降低复发率，提高生活质量。% Objective To identify the relevant factors for treatment outcomes in elderly depressive patients. Methods The clinical and laboratory data of 87 elderly patients with depression were col ected. The patients were evaluated with life events scale (LES), Eysenck's personality questionnaire (EPQ), social support rating scale (SSRS) and mini-mental state examinatlon (MMSE). The treatment outcomes were assessed with global assessment scale(GAS);GAS≤60 was classified as poor outcomes and GSA>60 as favorable outcomes. Logistic regression was used to identify the risk factors for poor outcomes. Results A-mong 87 patients 33 were classified as poor outcomes (37.9%) and 54 as favorable outcomes (62.1%) . Multivariate analysis of stepwise regression revealed that poor compliance, underlying chronic diseases, N-scale of the EPQ, psychotic symptoms and poor social support were risk factors for poor outcomes. Conclusion Some psychopathological, neuropsychological, family and social problem are risk factors for poor outcome in elderly patients with depression and should be intervened accordingly.
展开▼
