Objective:To observe the clinical curative effect of Honghua Ruyi Pill on chronic pelvic inflammatory disease, and to analysis its possible mechanism. Methods:A hundred patients with chronic pelvic inflammatory disease treated in our hospital were randomly divided into the routine treatment group and the observation group with 50 cases in each group. The routine treatment group received conventional antibiotic therapy, while Honghua Ruyi Pill was added for the observation group with the same therapy of routine treatment group. Both of the two groups were treated for 4 weeks and the changes of self-evaluation rating scale on pelvic inflammatory disease, and the concentration changes of cervical mucus TNF-α/IL–2 were compared between the two groups be-fore and after treatment. Results:1) The quality of life in both of the two groups after treatment were improved compared with that before the treatment and the increase of the observation group was more apparent compared with the routine treatment group, which showed statistically significant differences (P<0. 05). 2) The cervical mucus TNF-α protein expression levels of the two groups were similar before treatment, and the protein expression reduced in both of the two groups after intervention, the down-regulation in the observation group was more obvious. 3) The cervical mucus IL-2 expression levels of the two groups were close before the treatment, but the concentration of cervical mucus IL-2 increased in both of the two groups after intervention, while the increase in the observation group was more obvious. Conclusion:Honghua Ruyi Pill has ideal curative effect on pelvic inflammation, and may significantly improve patients′quality of life. Its mechanism may be related to the reduction of TNF-αand the up-regulation of IL-2 expression.%目的：：观察红花如意丸对慢性子宫附件炎的临床疗效,同时探析其部分作用机制。方法：将本院100例慢性子宫附件炎患者随机分为常规组及观察组,各50例。常规组接受常规抗生素治疗,观察组在常规组治疗方案基础上加用红花如意丸,2组均接受为期4周的治疗,疗程结束后比较2组子宫附件炎自评量表评分的变化以及宫颈黏液TNF-α/IL-2浓度变化。结果：1)2组患者治疗后生活质量均较治疗前有所提高,其中观察组提高的趋势更为明显,与常规组比较差异均有统计学意义(P<0．05)；2)2组治疗前宫颈黏液TNF-α蛋白表达水平相近,经过干预后2组宫颈黏液TNF-α蛋白表达均有所下调,其中观察组下调的趋势更明显；3)2组治疗前宫颈黏液IL-2表达水平相近,经过干预后2组宫颈黏液IL-2浓度均有所增加,其中观察组增加的趋势更明显。结论：红花如意丸对子宫附件炎有理想疗效,可明显提高患者生活质量,其作用机制可能与降低患者TNF-α上调IL-2表达有关。
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