糖尿病的发病机制正从过去的“胰岛素中心论”、“胰岛素、胰升糖素双激素论”向最新提出的“胰升糖素中心论”模式转变.胰升糖素过高可能对胰岛素不足时的糖代谢紊乱起着更重要的作用.抑制胰升糖素信号途径有望成为糖尿病新的治疗途径.%[Summary] The concept for the pathogenesis of diabetes is now changing from previous " insulinocentric model" and " insulin/glucagon bihormonal model" to a recent " glucagonocentric model".Glucagon excess rather than insulin deficiency may play a more important role in mediating the glucose derangement during insulin insufficiency.Antagonizing glucagon signaling pathway may become a potential therapeutic modality in diabetes.
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